Hopefully someone will have some insight into this...
I generate a PDF document using AutoCAD 2016's PDF writer, which I then print to our DesignJet 500 24" plotter. Reader DC offsets the document and cuts off some of it, while Acrobat DC prints correctly. Here are screen shots of the print dialogs from each application to illustrate the problem. The thumbnails accurately show how the documents print - Reader DC does cut off the document, while Acrobat Pro does not. To be clear: this is a problem with Reader DC, not with AutoCAD.
READER DC: It's hard to see, but the top and right margins are cutting off the document. The "print area" isn't centered.
Acrobat Pro DC: The document is perfectly centered with no clipping.